Details

The Biology and Therapeutic Application of Mesenchymal Cells


The Biology and Therapeutic Application of Mesenchymal Cells


1. Aufl.

von: Kerry Atkinson

445,99 €

Verlag: Wiley-Blackwell
Format: EPUB
Veröffentl.: 08.11.2016
ISBN/EAN: 9781118907290
Sprache: englisch
Anzahl Seiten: 1048

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

<p><i>The Biology and Therapeutic Application of Mesenchymal Cells</i> comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues.</p> <ul> <li>Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications</li> <li>Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models</li> <li>Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues</li> <li>Written and edited by leaders in the field</li> </ul> <p><i>The Biology and Therapeutic Application of Mesenchymal Cells</i> is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.</p>
Contributors, xxvii <p>Editor’s Preface, xxxv</p> <p><b>Section I: An overview of mesenchymal stem cells and mesenchymal stromal cells</b></p> <p>1 The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome, 3<br /><i>Kerry Atkinson</i></p> <p>2 The nomenclature of mesenchymal stem cells and mesenchymal stromal cells, 8<br /><i>Armand Keating</i></p> <p><b>Section II: The isolation and ex vivo expansion of mesenchymal stromal cells</b></p> <p>3 The isolation and expansion of mesenchymal stromal cells from bone marrow, 13<br /><i>Celena F. Heazlewood</i></p> <p>4 The biology and clinical applications of mesenchymal stromal cells derived from human gestational tissues, 24<br /><i>Celena F. Heazlewood</i></p> <p>5 Human placenta-derived mesenchymal stem/stromal cells: fetal and maternal origins and critical parameters for<br />ex vivo expansion, 32<br /><i>Rebecca A. Pelekanos and Varda S. Sardesai</i></p> <p><b>Section III: The cellular and molecular biology of mesenchymal stromal cells</b></p> <p>6 Epigenetic regulation of mesenchymal stem/stromal cell growth and multipotentiality, 41<br /><i>Sarah Elizabeth Hemming, Dimitrios Cakouros, and Stan Gronthos</i></p> <p>7 Biological changes in human mesenchymal stromal cells during monolayer culture, 58<br /><i>Marietta Herrmann and Jennifer J. Bara</i></p> <p>8 The effect of three-dimensional aggregates on the biology of mesenchymal stromal cells, 75<br /><i>Yijun Liu, Ang-Chen Tsai, Xuegang Yuan, and Teng Ma</i></p> <p>9 Cell–cell signaling pathways that regulate mesenchymal stromal cell differentiation, 91<br /><i>Leah Etheridge, Rebecca A. Mason, Fatima Saleh, and Paul Genever</i></p> <p>10 Regulation of mitochondrial transport in mesenchymal stromal cells, 104<br /><i>Shravani Mukherjee, Naveen K. Bhatraju, Tanveer Ahmad, and Anurag Agrawal</i></p> <p>11 The regulation of adipogenesis from adipose-derived stem/stromal cells, 114<br /><i>Lin Chen and Lei Liu</i></p> <p>12 Modulation of osteogenic differentiation in mesenchymal stromal cells, 131<br /><i>Sean Gaynard, Jessica Hayes, and Mary Murphy</i></p> <p>13 The role of glycogen synthase kinase-3 inhibitors on bone remodeling, 148<br /><i>K. Jane Escott and Patrick J. O’Shea</i></p> <p>14 Early molecular events during in vitro chondrogenesis, 167<br /><i>Tommy A. Karlsen, Rune B. Jakobsen, and Jan E. Brinchmann</i></p> <p>15 The role of the extracellular matrix in the differentiation of mesenchymal stromal cells, 191<br /><i>Peishun Shou, Qing Chen, and Yufang Shi</i></p> <p>16 Effects of hypoxic culture on bone marrow multipotent mesenchymal stromal cells: from bench to bedside, 196<br /><i>Shih-Chieh Hung</i></p> <p>17 The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells, 208<br /><i>Adisri Charoenpanich, Josephine Bodle, and Elizabeth Loboa</i></p> <p>18 The evolving concept of mesenchymal stromal cells in regenerative medicine: from cell differentiation to<br />secretome, 222<br /><i>F.G. Teixeira, A. Pires, S.C. Serra, N. Sousa, and A.J. Salgado</i></p> <p>19 The secretome of mesenchymal stem/stromal cells undergoing chondrogenic differentiation and those undergoing osteogenic or adipogenic differentiation, 236<br />Beatriz Rocha, Francisco J. Blanco, and Cristina Ruiz-Romero</p> <p>20 Mesenchymal stromal cell extracellular vesicles/exosomes, 250<br /><i>Ronne Wee Yeh Yeo, Ruenn Chai Lai, and Sai Kiang Lim</i></p> <p>21 Role of tunneling nanotube crosstalk with distressed cardiomyocytes in controlling the heart repair potential of mesenchymal stromal cells, 264<br /><i>Anne-Marie Rodriguez and Meriem Mahrouf-Yorgov</i></p> <p>22 The preferential homing of mesenchymal stromal cells to sites of inflammation, 286<br /><i>Catherine Sullivan</i></p> <p>23 The role of chemokines in mesenchymal stromal cell homing to sites of inflammation, including infarcted<br />myocardium, 314<br /><i>Shan Wang and Yaojiong Wu</i></p> <p>24 Live cell imaging and single cell tracking of’mesenchymal stromal cells in vitro, 323<br /><i>James A. Cornwell, Maria Z. Gutierrez, Richard P. Harvey and Robert E. Nordon</i></p> <p>25 The role of mesenchymal stem/stromal cells in angiogenesis, 347<br /><i>Annelies Bronckaers and Ivo Lambrichts</i></p> <p>26 The relationship between mesenchymal stromal cells and endothelial cells, 366<br /><i>Seyed Mahdi Nassiri and Reza Rahbarghazi</i></p> <p>27 The radioresistance of mesenchymal stromal cells and their potential role in the management of radiation injury, 391<br /><i>Tara Sugrue, Irene Calvo-Asensio, and Rhodri Ceredig</i></p> <p>28 The implications of multipotent mesenchymal stromal cells in tumor biology and therapy, 415<br /><i>Pratika Y. Hernanda, Maikel P. Peppelenbosch, and Qiuwei Pan</i></p> <p>29 Mesenchymal stem/stromal cell therapy: mechanism of action and host response, 426<br /><i>Aideen Ryan, Mary Murphy, and Frank Barry</i></p> <p>30 The differences between mesenchymal stromal cells and fibroblasts, 441<br /><i>Luigi Balducci, Sharon Natasha Cox, and Giulio Alessandri</i></p> <p>31 Derivation of mesenchymal stem/stromal cells from induced pluripotent stem cells, 456<br /><i>Rebecca A. Pelekanos</i></p> <p>32 The role of mesenchymal stem cells in hematopoiesis, 467<br /><i>Jean-Pierre Levesque, Rebecca N. Jacobsen, and Ingrid G. Winkler</i></p> <p>33 The modulatory effects of mesenchymal stromal cells onthe innate immune system, 481<br /><i>Ko-Jiunn Liu, Men-Luh Yen, Li-Tzu Wang, and B. Linju Yen</i></p> <p>34 The modulatory effects of mesenchymal stromal cells on the adaptive immune system, 490<br /><i>B. Linju Yen, Ko-Jiunn Liu, Men-Luh Yen, and Huey-Kang Sytwu</i></p> <p>35 The role of mesenchymal stromal cells in the repair of acute organ injury, 496<br /><i>A.A. Temnov, A.V. Vagabov, A.N. Sklifas, V.I. Novoselov, and Y.A. Belyi</i></p> <p>36 The use of mesenchymal stromal cells in the treatment of diseases of the cornea, 524<br /><i>Damien G. Harkin, Allison J. Sutherland, Laura J. Bray, Leanne Foyn, Fiona J. Li, and Brendan G. Cronin</i></p> <p>37 The role of paracrine factors secreted by mesenchymal stromal cells in acute tissue injury, 544<br /><i>Ying Wang, Tania Velletri, Chunxing Zheng, and Yufang Shi</i></p> <p>38 Treatment of lung disease by mesenchymal stromal cell extracellular vesicles, 553<br /><i>Antoine Monsel, Ying-gang Zhu, Varun Gudapati, and Jae-Woo Lee</i></p> <p>39 Evaluating mesenchymal stem/stromal cells for treatment of asthma and allergic rhinitis, 573<br /><i>Tatyana Gavrilova, Saritha Kartan, Lauren S. Sherman, Oleta A. Sandiford, and Pranela Rameshwar</i></p> <p>40 Stem cell therapies for Huntington’s disease, 581<br /><i>A.T. Crane, J. Rossignol, and G. L. Dunbar</i></p> <p><b>Section IV: The role of bioengineering in the therapeutic applications of mesenchymal stromal cells</b></p> <p>41 Endometrial mesenchymal stromal cell and tissue engineering for pelvic organ prolapse repair, 601<br /><i>Shanti Gurung, Jerome A. Werkmeister, and Caroline E. Gargett</i></p> <p>42 Closed automated large-scale bioreactors for manufacturing mesenchymal stromal cells for clinical use, 616<br /><i>Kerry Atkinson, Nicholas Timmins, G. Kiel, Celena Heazlewood, Michael Doran, and Gary Brooke</i></p> <p><b>Section V: GMP manufacturing of mesenchymal stromal cells for clinical use</b></p> <p>43 Current good manufacturing practice for the isolation and ex vivo expansion of mesenchymal stromal cells derived from term human placenta for use in clinical trials, 621<br /><i>Kerry Atkinson, Dahlia Khalil, Celena Heazlewood, and Nina Ilic</i></p> <p>44 A comparison of high-tier regulatory documents pertaining to biologic drugs including mesenchymal stromal cells in Australia, Europe, and the USA using a manual documentary analysis, 628<br /><i>Nina Ilic</i></p> <p><b>Section VI: The therapeutic application of mesenchymal stromal cells</b></p> <p>45 The use of mesenchymal stromal cells in acute and chronic heart disease, 647<br /><i>Ariel Wolf, Wayne Balkan, and Joshua Hare</i></p> <p>46 The role of mesenchymal stem/stromal cells in the management of critical limb ischemia, 661<br /><i>P.K. Gupta, Chullikana Anoop, Balasubramanian Sudha, R Mathiazhagan, Raj Swathi Sundar, and Majumdar Anish Sen</i></p> <p>47 The role of mesenchymal stromal cells in the management of musculoskeletal disorders, 677<br /><i>Stefan Zwingenberger, Ishaq Ojodu, Maik Stiehler, and Stuart B. Goodman</i></p> <p>48 The potential role of bone marrow mesenchymal stromal cells in the treatment of ischemic stroke, 690<br /><i>Yujun Pan and Ruohan Sun</i></p> <p>49 The role of mesenchymal stromal cells in spinal cord injury, 714<br /><i>P. Jendelova, L. Machova-Urdzikova, and E. Sykova</i></p> <p>50 The role of mesenchymal stromal cells in the treatment of ulcerative colitis and Crohn’s disease, 730<br /><i>Céline Gregoire, Chantal Lechanteur, Alexandra Briquet, Etienne Baudoux, Olivier Giet, Olivier Delloye, Frédéric Baron, Edouard Louis, and Yves Beguin</i></p> <p>51 Mesenchymal stromal cells targeting kidney disease: benefits of a combined therapeutic approach, 754<br /><i>Brooke M. Huuskes and Sharon D. Ricardo</i></p> <p>52 The biology and potential clinical applications of mesenchymal stromal cells in diseases of the lung, 770<br /><i>Yuben P. Moodley, Jesse D. Armitage, and Dino B.A. Tan</i></p> <p>53 The role of mesenchymal stromal cells in diseases of the lung, 787<br /><i>Kerry Atkinson</i></p> <p>54 Mesenchymal stromal cells for the treatment of’autoimmune diseases, 794<br /><i>Christopher N. Lewis and Jacques Galipeau</i></p> <p>55 The role of mesenchymal stromal cells in bacterial infection, 814<br /><i>Sailaja Ghanta, Konstantin Tsoyi, and Mark A. Perrella</i></p> <p>56 The use of mesenchymal stromal cells in solid organ transplantation, 825<br /><i>Céline Gregoire, Alexandra Briquet, François Jouret, Chantal Lechanteur, Etienne Baudoux, Olivier Giet, Olivier Delloye, Frédéric Baron, Olivier Detry, and Yves Beguin</i></p> <p>57 The role of mesenchymal stromal cells in allogeneic hematopoietic stem cell transplantation, 836<br /><i>Kerry Atkinson</i></p> <p>58 The role of mesenchymal stromal cells in the management of skin wounds, 841<br /><i>Sung-Whan Kim</i></p> <p>59 The role of mesenchymal stromal cells in skin wound healing, 845<br /><i>Miao Teng and Hengshu Zhang</i></p> <p><b>Section VII: Mesenchymal stromal cells as delivery vehicles for therapeutic agents</b></p> <p>60 The role of mesenchymal stromal cells in human brain tumors, 859<br /><i>Brittany C. Parker Kerrigan, Tal Shahar, Shinji Yamashita, and Frederick F. Lang</i></p> <p>61 Mesenchymal stromal cells as gene delivery vehicles to treat nonmalignant diseases, 873<br /><i>Julie R. Beegle, Jan A. Nolta, and Fernando A. Fierro</i></p> <p>62 Gene therapy for cancer using mesenchymal stromal cells, 892<br /><i>Ryosuke Uchibori and Keiya Ozawa</i></p> <p><b>Section VIII: The present and the future</b></p> <p>63 Breaking news, 901<br /><i>Kerry Atkinson</i></p> <p>64 Reconciling the stem cell and paracrine paradigms of mesenchymal stem cell function, 912<br /><i>Siddaraju V. Boregowda and Donald G. Phinney</i></p> <p>Glossary, 927</p> <p>Index, 949</p>
<b>Kerry Atkinson</b>, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
<p><i>The Biology and Therapeutic Application of Mesenchymal Cells</i> comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues.</p> <ul> <li>Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications</li> <li>Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models</li> <li>Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues</li> <li>Written and edited by leaders in the field</li> </ul> <p><i>The Biology and Therapeutic Application of Mesenchymal Cells</i> is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.</p>

Diese Produkte könnten Sie auch interessieren:

The Biology of Echinostomes
The Biology of Echinostomes
von: Bernard Fried, Rafael Toledo
PDF ebook
149,79 €
Antibiotic Policies
Antibiotic Policies
von: Ian M. Gould, Jos W.M. van der Meer
PDF ebook
213,99 €
Tropical and Parasitic Infections in the Intensive Care Unit
Tropical and Parasitic Infections in the Intensive Care Unit
von: Charles Feldman, George A. Sarosi
PDF ebook
149,79 €