Details

Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity


Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity


Current Topics in Microbiology and Immunology, Band 410

von: Akihiko Yoshimura

178,49 €

Verlag: Springer
Format: PDF
Veröffentl.: 25.11.2017
ISBN/EAN: 9783319689296
Sprache: englisch

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Beschreibungen

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
Regulatory T cells: molecular and cellular basis for immunoregulation.- Overview of LAG-3- expressing, IL-10-producing regulatory T cells.- Regulatory Dendritic Cells.- Role of PD-1 in immunity and diseases.- CTLA-4, an essential immune-checkpoint for T cell activation.- Tim-3, Lag-3, and TIGIT.- SOCS1: regulator of T cells in autoimmunity and cancer.- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity.- Immune regulation by ubiquitin tagging as checkpoint code.- MicroRNA in Immune Regulation.
Akihiko Yoshimura, PhD Department of Microbiology and Immunology, Keio University School of Medicine 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan Phone: +81-3-5363-3483 FAX: +81-3-5360-1508 yoshimura@a6.keio.jp
This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
Addresses all aspects of the molecular and cellular biology of extracellular and intracellular immune checkpoint regulators Promotes the understanding and application of extended immune checkpoint regulators Offers new strategies for the therapy of various diseases, such as autoimmune diseases and cancer 
Addresses all aspects of the molecular and cellular biology of extracellular and intracellular immune checkpoint regulators Promotes the understanding and application of extended immune checkpoint regulators Offers new strategies for the therapy of various diseases, such as autoimmune diseases and cancer 

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